CASE REPORT: PERIVENTRICULAR HETEROTOPIA AND EARLY-ONSET BIPOLAR DISORDER IN ADOLESCENT PATIENT WITH HISTORY OF CHILDHOOD ATTENTION DEFICIT HYPERACTIVITY DISORDER

Case report: Periventricular heterotopia and early-onset bipolar disorder in adolescent patient with history of childhood attention deficit hyperactivity disorder

Periventricular heterotopia (PH) is a developmental malformation in the brain.Because the clinical symptoms are heterogeneous, few studies have investigated the psychiatric symptoms Ringette Visor associated with PH.We describe the case of a 17-year-old male with bipolar disorder (BD), who had been treated for attention deficit-hyperactivity disord

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Distinct target genes and effector processes appear to be critical for p53-activated responses to acute DNA damage versus p53-mediated tumour suppression

The p53 tumour suppressor is the most frequently mutated gene in human cancer.This transcription factor can be PEACH activated by diverse cellular stresses, including DNA damage and oncogene activation.Through transcriptional induction of appropriate target genes, p53 can stimulate activity in a broad range of effector pathways, most notably cell c

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